Endotoxin Increases Sleep and Brain Allopregnanolone Concentrations in Newborn Lambs
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چکیده
منابع مشابه
Alveolar hypoxia increases lung fluid filtration in unanesthetized newborn lambs.
We studied the pulmonary vascular response to hypoxia and associated transvascular flux of fluid into the lungs of newborn lambs. After a 2-hour baseline period, 14 unanesthetized lambs, 1-3 weeks old, breathed 10-12% oxygen in nitrogen for 3-6 hours. We measured steady state lung lymph flow, pulmonary arterial and left atrial pressures, blood flow to the lungs, and the concentration of protein...
متن کاملNewborn Lambs
We have previously shown that the pulmonary venoconstriction produced by a stable thromboxane A2 analogue (STAJ is attenuated by prostacyclin (PGIi), but PGI, increases the STA2-induced edema. The present study was designed to determine the effects of STA2 and PGI2 on the fluid balance in isolated blood-perfused newborn lamb lungs. Vascular permeability was evaluated by use of the fluid filtrat...
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UNLABELLED We used a mass spectrometry-based assay for identifying the endotoxin (lipopolysaccharide, LPS) marker (R)-3-hydroxytetradecanoic acid in cigarette smoke particles and found that smoking involved inhalation of 17.4 pmol of endotoxin per each smoked cigarette. Indoor exposure to environmental tobacco smoke (ETS) entailed inhalation of 12.1 pmol of LPS/m3 air, an amount that was 120 ti...
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We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and 80%, but not 90% of gestation, and decreased brain water content in fetuses. Our objective was to examine the effects of postnatal corticosteroids on regional blood-brain barrier permeability and brain water content in newborn lambs. Three dexamethasone treatment groups were studied in 3- to 5...
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Intense exercise and sleep deprivation affect the amount of homeostatically regulated slow wave sleep in the subsequent sleep period. Since brain energy metabolism plays a decisive role in the regulation of behavioral states, we determined the concentrations of nucleotides and nucleosides: phosphocreatine, creatine, ATP, ADP, AMP, adenosine, and inosine after moderate and exhaustive treadmill e...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2002
ISSN: 0031-3998,1530-0447
DOI: 10.1203/01.pdr.0000036604.14242.94